INNOVATING BIOLOGY
EVerse Biotechnology:
reprogramming agriculture with Bacterial Extracellular Vesicles
What we do:
EVerse Biotechnology is an ag-tech startup pioneering the use of extracellular vesicles (EVs) in agriculture, unlocking a new generation of precision biological solutions with applications across biotechnology and human health.
THE PROBLEM WITH CONVENTIONAL AGRICULTURE
Increasing resistance to chemical pesticides
→ Reduced efficacy against key pests (e.g., soybean pests).
Environmental impact
→ Soil degradation, water contamination, biodiversity loss.
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Regulatory pressure
→ Restrictions on agrochemicals worldwide.
Non-specific toxicity
→ Harm to beneficial organisms (pollinators, microbiota).
Rising costs for farmers
→ More applications needed for the same effect.
Technology
Bacterial extracellular vesicles as a delivery platform
Bacterial extracellular vesicles (bEVs) are nano-sized particles naturally released by bacteria.
These vesicles act as highly efficient delivery systems, transporting proteins, metabolites, lipids, and nucleic acids.
At EVerse, we engineer and harness bEVs as programmable biological carriers that deliver functional molecules directly to plants, insects, and microbial pathogens.
Transmission electron microscopy (TEM) image of a bacterial cell and associated extracellular vesicles (EVs). Getulio Oliveira, unpublished data.
Why bEVs Outperform Whole Bacterial Cells as biologicals
Whole Bacterial Cells (Conventional biologicals)
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Living organisms → unpredictable behavior in the field
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Depend on survival, colonization, and environmental conditions
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Delayed mode of action (require growth and metabolite production)
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Risk of ecological imbalance and horizontal gene transfer
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More complex and slower regulatory approval pathways
bEVs (EVerse Technology)
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Cell-free system → highly controlled and reproducible, do not require survival or colonization
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Pre-loaded with defined bioactive cargo (proteins, metabolites, RNA)
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Non-replicative → improved biosafety profile
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More stable and easier to formulate and store
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Potentially simplified regulatory pathway
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Bacterial extracellular vesicles (bEV)-based control of soybean pest (Euschistus heros)
Development of bacterial extracellular vesicle (bEV)-based bioinsecticides targeting the neotropical brown stink bug, a major pest impacting soybean production in Latin America.
🟢 Patent pending
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bEVs for Lepidopteran pest control
Exploration of bEV-mediated delivery of insecticidal molecules targeting key Lepidopteran pests affecting major crops.
🟡 Early-stage development
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bEV-based strategies for Dipteran pest control
Development of bEV-based platforms targeting Dipteran species, including agricultural and human-relevant insect pests.
🟡 Early-stage development
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bEV-mediated delivery of ssDNA against Xanthomonas spp.
Engineering bacterial extracellular vesicles for the delivery of single-stranded DNA (ssDNA) to control Xanthomonas spp., a major bacterial pathogen affecting tomato and other crops.
🟡 Early-stage development
Advancing bacterial extracellular vesicle technologies for next-generation agricultural solutions
Ongoing Projects
Why Invest in EVerse Technology
Pioneering a new class of bioinputs powered by extracellular vesicles.
Explosive growth of the biologicals market
Favorable and evolving regulatory framework
Brazil: a global agricultural powerhouse
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The next frontier: extracellular vesicle-based biologicals
TEAM
Founder and CEO
Profiles & Publications
Getulio Oliveira, PhD, is the Founder and CEO of EVerse, a biotechnology company developing extracellular vesicle-based solutions for agriculture and human health.
With over 15 years of experience in extracellular vesicle research, he specializes in molecular biology, proteomics, nanotechnology, and vesicle characterization. He completed his postdoctoral training at Beth Israel Deaconess Medical Center, Harvard Medical School, and has collaborated with leading academic and biotechnology institutions.
He currently develops his research at Universidade Católica de Brasília, translating extracellular vesicle science into scalable biotechnological applications.
Partners and collaborators
CONTACT
Call to Action:
Interested in partnerships, collaborations, or investment opportunities?
Connect with us to explore how we can accelerate the development and commercialization of extracellular vesicle-based solutions together.